Is there a thematic anti-Star Trek?
That is to say, a show which consistantly regards the human condition, but rather than continually refirming humanity's capability and nature, takes a pessimistic view; maybe it has a cynical take on human nature, indicates that nothing will every really improve, or perhaps it's implied that humanity can only every successfully strive so far; there's a hard cap on our advancement as a species, say.
I can think of plenty of shows with a jaded viewpoint, but nothing quite along these lines, at least with consistancy. Doesn't need to be scifi. I'm concerned purely with theme.